fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models | Zendy

Rajesh V. Dudhani | Zendy; John Turnidge | Zendy; Roger L. Nation | Zendy; Jian Li | Zendy

Open Access

fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models

Author(s) -

Rajesh V. Dudhani,

John Turnidge,

Roger L. Nation,

Jian Li

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq226

Subject(s) - colistin , acinetobacter baumannii , medicine , pharmacokinetics , pharmacodynamics , pharmacology , acinetobacter , microbiology and biotechnology , antibiotics , pseudomonas aeruginosa , biology , bacteria , genetics

To elucidate the pharmacokinetic/pharmacodynamic (PK/PD) index that predicts colistin efficacy against Acinetobacter baumannii in neutropenic murine thigh and lung infection models, and to determine the extent of the emergence of resistance in vivo to colistin.

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