Depletion of resuscitation-promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis | Zendy

Bavesh D Kana | Zendy; Valerie Mizrahi | Zendy; Bhavna G. Gordhan | Zendy

Open Access

Depletion of resuscitation-promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis

Author(s) -

Bavesh D Kana,

Valerie Mizrahi,

Bhavna G. Gordhan

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq199

Subject(s) - mycobacterium tuberculosis , resuscitation , tuberculosis , virulence , microbiology and biotechnology , medicine , virulence factor , drug , drug resistance , biology , gene , pharmacology , anesthesia , genetics , pathology

Mycobacterium tuberculosis has five homologues of the muralytic resuscitation-promoting factor (Rpf), which are collectively dispensable for growth in vitro, but are required for resuscitation from a non-culturable state and for virulence in a mouse infection model. Our study was aimed at assessing the drug susceptibility of mutants lacking all five rpf genes.

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