Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2 | Zendy

David M. Whiley | Zendy; Namraj Goire | Zendy; Stephen B. Lambert | Zendy; Sanghamitra Ray | Zendy; E. Athena Limnios | Zendy; Michael D. Nissen | Zendy; T. P. Sloots | Zendy; John W. Tapsall | Zendy

Open Access

Reduced susceptibility to ceftriaxone in Neisseria gonorrhoeae is associated with mutations G542S, P551S and P551L in the gonococcal penicillin-binding protein 2

Author(s) -

David M. Whiley,

Namraj Goire,

Stephen B. Lambert,

Sanghamitra Ray,

E. Athena Limnios,

Michael D. Nissen,

T. P. Sloots,

John W. Tapsall

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq187

Subject(s) - mtrr , neisseria gonorrhoeae , ceftriaxone , cephalosporin , penicillin , penicillin binding proteins , microbiology and biotechnology , biology , sexually transmitted disease , antibacterial agent , spectinomycin , genetics , virology , allele , antibiotics , gene , syphilis , human immunodeficiency virus (hiv) , methylenetetrahydrofolate reductase

Reduced susceptibility to extended-spectrum cephalosporins in Neisseria gonorrhoeae has, to date, been associated with three alterations: a mosaic penA allele encoding the penicillin-binding protein 2 (PBP2); A-del-mtrR, an adenine deletion in the mtrR promoter; and penB, comprising mutated alleles of PorBIb. In this study, we examined an association between reduced susceptibility to ceftriaxone and additional mutations in gonococcal PBP2.

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