Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics | Zendy

Marta Ulldemolins | Zendy; Jason A. Roberts | Zendy; Steven C. Wallis | Zendy; Jordi Rello | Zendy; Jeffrey Lipman | Zendy

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Flucloxacillin dosing in critically ill patients with hypoalbuminaemia: special emphasis on unbound pharmacokinetics

Author(s) -

Marta Ulldemolins,

Jason A. Roberts,

Steven C. Wallis,

Jordi Rello,

Jeffrey Lipman

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq184

Subject(s) - flucloxacillin , pharmacokinetics , dosing , medicine , pharmacology , population , pharmacodynamics , nonmem , staphylococcus aureus , biology , environmental health , bacteria , genetics

To describe the total and unbound plasma concentration-time profiles for highly protein-bound flucloxacillin (95%-97% protein binding) in critically ill patients with hypoalbuminaemia and without severe renal dysfunction, and to use population pharmacokinetic modelling and Monte Carlo simulations to assess the probability of target attainment against an MIC distribution.

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