Activity of chequerboard combinations of ceftaroline and NXL104 versus -lactamase-producing Enterobacteriaceae | Zendy

Shazad Mushtaq | Zendy; M. Warner | Zendy; G. Williams | Zendy; Ian A. Critchley | Zendy; David M. Livermore | Zendy

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Activity of chequerboard combinations of ceftaroline and NXL104 versus -lactamase-producing Enterobacteriaceae

Author(s) -

Shazad Mushtaq,

M. Warner,

G. Williams,

Ian A. Critchley,

David M. Livermore

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq161

Subject(s) - cephalosporin , enterobacteriaceae , microbiology and biotechnology , biology , chemistry , antibiotics , escherichia coli , genetics , gene

Ceftaroline is a novel oxyimino-cephalosporin, strongly active against methicillin-resistant staphylococci and pneumococci. It is active against Enterobacteriaceae too, but is labile to common beta-lactamases, including AmpC and extended-spectrum types. To counteract these enzymes, ceftaroline is also being developed combined with NXL104, a beta-lactamase inhibitor.

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