TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium | Zendy

Tsukasa Horiyama | Zendy; Akihito Yamaguchi | Zendy; Kunihiko Nishino | Zendy

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TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium

Author(s) -

Tsukasa Horiyama,

Akihito Yamaguchi,

Kunihiko Nishino

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq160

Subject(s) - salmonella enterica , efflux , microbiology and biotechnology , salmonella , multiple drug resistance , serotype , enterobacteriaceae , biology , virology , bacteria , antibiotics , escherichia coli , genetics , gene

TolC is a major outer membrane channel and it plays an important role in the excretion of a wide range of molecules, including antibiotics. A recent study has shown that Salmonella enterica serovar Typhimurium has nine functional drug efflux pumps; however, the TolC dependency of these efflux pumps remains to be studied in detail. The aim of this study was to investigate the TolC dependency of multidrug efflux pumps in this organism.

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