Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin | Zendy

Karoline Sidelmann Brinch | Zendy; Paul M. Tulkens | Zendy; Françoise Van Bambeke | Zendy; Niels FrimodtMøller | Zendy; Niels Høiby | Zendy; H. H. Kristensen | Zendy

Open Access

Intracellular activity of the peptide antibiotic NZ2114: studies with Staphylococcus aureus and human THP-1 monocytes, and comparison with daptomycin and vancomycin

Author(s) -

Karoline Sidelmann Brinch,

Paul M. Tulkens,

Françoise Van Bambeke,

Niels FrimodtMøller,

Niels Høiby,

H. H. Kristensen

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq159

Subject(s) - daptomycin , staphylococcus aureus , intracellular , microbiology and biotechnology , vancomycin , antibiotics , peptide , bacteria , biology , chemistry , biochemistry , genetics

Staphylococcus aureus survives inside eukaryotic cells. Our objective was to assess the activity of NZ2114, a novel peptidic antibiotic, against intracellular S. aureus in comparison with established antistaphylococcal agents acting on the bacterial envelope with a distinct mechanism.

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