Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates | Zendy

Smritilekha Bera | Zendy; George G. Zhanel | Zendy; Frank Schweizer | Zendy

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Antibacterial activity of guanidinylated neomycin B- and kanamycin A-derived amphiphilic lipid conjugates

Author(s) -

Smritilekha Bera,

George G. Zhanel,

Frank Schweizer

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq083

Subject(s) - kanamycin , neomycin , antibacterial activity , microbiology and biotechnology , pseudomonas aeruginosa , staphylococcus epidermidis , staphylococcus aureus , chemistry , antibacterial agent , biology , antibiotics , bacteria , genetics

Neomycin B exhibits poor antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa, while kanamycin A shows weak activity against MRSA, methicillin-resistant Staphylococcus epidermidis (MRSE) and P. aeruginosa. The main purpose of this work was to study whether lipid conjugation of guanidinylated neomycin B- and kanamycin A-derived cationic headgroups could restore antibacterial activity against neomycin B- and kanamycin A-resistant strains, while retaining antibacterial activity against non-resistant strains.

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