Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes | Zendy

Omar Janneh | Zendy; P. G. Bray | Zendy; E. Jones | Zendy; Christoph Wyen | Zendy; Peter Chiba | Zendy; David Back | Zendy; Saye Khoo | Zendy

Open Access

Concentration-dependent effects and intracellular accumulation of HIV protease inhibitors in cultured CD4 T cells and primary human lymphocytes

Author(s) -

Omar Janneh,

P. G. Bray,

E. Jones,

Christoph Wyen,

Peter Chiba,

David Back,

Saye Khoo

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq082

Subject(s) - ritonavir , saquinavir , lopinavir , atazanavir , pharmacology , chemistry , intracellular , biochemistry , biology , virology , viral load , human immunodeficiency virus (hiv) , antiretroviral therapy

The intracellular and plasma concentrations of HIV protease inhibitors (HPIs) vary widely in vivo. It is unclear whether there is a concentration-dependent effect of HPIs such that at increasing concentration they may either block their own efflux (leading to 'autoboosting') or influx (leading to saturability/decreased intracellular accumulation).

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