Salicylate reduces the antimicrobial activity of ciprofloxacin against extracellular Salmonella enterica serovar Typhimurium, but not against Salmonella in macrophages | Zendy

Efrat Hartog | Zendy; Ofir Menashe | Zendy; Edna Kler | Zendy; Sima Yaron | Zendy

Open Access

Salicylate reduces the antimicrobial activity of ciprofloxacin against extracellular Salmonella enterica serovar Typhimurium, but not against Salmonella in macrophages

Author(s) -

Efrat Hartog,

Ofir Menashe,

Edna Kler,

Sima Yaron

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq077

Subject(s) - salmonella enterica , microbiology and biotechnology , salmonella , ciprofloxacin , antimicrobial , serotype , enterobacteriaceae , biology , antibiotics , bacteria , escherichia coli , biochemistry , genetics , gene

Salicylate, a potent inducer of the MarA activator in Salmonella enterica, is the principal metabolite of aspirin, which is often consumed for medicinal and cosmetic uses. Our research was aimed at testing if salicylate activates the mar regulon in macrophage-associated Salmonella (intracellular bacteria), and investigating its effects on bacterial susceptibility to ciprofloxacin extracellularly and intracellularly.

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