Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro | Zendy

Anne Sandberg | Zendy; Kim Jensen | Zendy; Pierre Baudoux | Zendy; Françoise Van Bambeke | Zendy; Paul M. Tulkens | Zendy; Niels FrimodtMøller | Zendy

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Intra- and extracellular activity of linezolid against Staphylococcus aureus in vivo and in vitro

Author(s) -

Anne Sandberg,

Kim Jensen,

Pierre Baudoux,

Françoise Van Bambeke,

Paul M. Tulkens,

Niels FrimodtMøller

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq052

Subject(s) - linezolid , staphylococcus aureus , in vivo , in vitro , microbiology and biotechnology , extracellular , micrococcaceae , antibacterial agent , methicillin resistant staphylococcus aureus , staphylococcal infections , staphylococcus , chemistry , antibiotics , medicine , bacteria , biology , vancomycin , biochemistry , genetics

Treatment of Staphylococcus aureus infections remains problematic (slow responses and frequent recurrences). Intracellular persistence of the S. aureus could explain those difficulties because of impaired intracellular efficacy of antibiotics. Our aim was to study linezolid for its intracellular activity.

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