Combinations of maggot excretions/secretions and antibiotics are effective against Staphylococcus aureus biofilms and the bacteria derived therefrom | Zendy

Mariena J. A. van der Plas | Zendy; C. Dambrot | Zendy; H. C. M. Dogterom-Ballering | Zendy; S. Kruithof | Zendy; Jaap T. van Dissel | Zendy; Peter H. Nibbering | Zendy

Open Access

Combinations of maggot excretions/secretions and antibiotics are effective against Staphylococcus aureus biofilms and the bacteria derived therefrom

Author(s) -

Mariena J. A. van der Plas,

C. Dambrot,

H. C. M. Dogterom-Ballering,

S. Kruithof,

Jaap T. van Dissel,

Peter H. Nibbering

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq042

Subject(s) - microbiology and biotechnology , biofilm , daptomycin , staphylococcus aureus , clindamycin , antibiotics , vancomycin , bacteria , biology , maggot , genetics , botany

Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. Previously we reported that maggot excretions/secretions (ES) break down Staphylococcus aureus biofilms but do not kill the bacteria. As many antibiotics are not effective against biofilms we assessed the effect of combinations of ES and antibiotics on S. aureus biofilms and on the survival of the bacteria released from the biofilms.

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