Factors associated with proviral DNA HIV-1 tropism in antiretroviral therapy-treated patients with fully suppressed plasma HIV viral load: implications for the clinical use of CCR5 antagonists | Zendy

Cathia Soulié | Zendy; S. Fourati | Zendy; Sidonie Lambert-Niclot | Zendy; I. Malet | Zendy; Marc Wirden | Zendy; Roland Tubiana | Zendy; MarcAntoine Valantin | Zendy; Christine Katlama | Zendy; Vincent Cálvez | Zendy; AnneGeneviève Marcelin | Zendy

Open Access

Factors associated with proviral DNA HIV-1 tropism in antiretroviral therapy-treated patients with fully suppressed plasma HIV viral load: implications for the clinical use of CCR5 antagonists

Author(s) -

Cathia Soulié,

S. Fourati,

Sidonie Lambert-Niclot,

I. Malet,

Marc Wirden,

Roland Tubiana,

MarcAntoine Valantin,

Christine Katlama,

Vincent Cálvez,

AnneGeneviève Marcelin

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq029

Subject(s) - viral load , tropism , tissue tropism , virology , ccr5 receptor antagonist , immunology , nadir , cd4 t cell , viral replication , virus , v3 loop , biology , medicine , t cell , antibody , chemokine , inflammation , chemokine receptor , immune system , satellite , engineering , epitope , aerospace engineering

Most treated HIV-1 patients have undetectable viral loads and the strategies for managing long-term side effects may involve a new class of antiretroviral-like CCR5 antagonists. Tropism determination based on proviral DNA sequence is necessary for patients with a fully suppressed plasma viral load, as assays analysing DNA phenotypes have yet to be developed. We aimed to analyse HIV-1 tropism using proviral DNA sequencing and the associated factors, in a group of patients on antiretroviral (ARV) treatment with an undetectable viral load in plasma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research