Fungicidal activity of miconazole against Candida spp. biofilms | Zendy

Davy Vandenbosch | Zendy; Kevin Braeckmans | Zendy; Hans J. Nelis | Zendy; Tom Coenye | Zendy

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Fungicidal activity of miconazole against Candida spp. biofilms

Author(s) -

Davy Vandenbosch,

Kevin Braeckmans,

Hans J. Nelis,

Tom Coenye

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkq019

Subject(s) - miconazole , candida albicans , microbiology and biotechnology , biofilm , fungicide , azole , reactive oxygen species , in vitro , corpus albicans , biology , chemistry , antifungal , biochemistry , bacteria , botany , genetics

Although azole antifungals are considered to be fungistatic, miconazole has fungicidal activity against planktonic Candida albicans cells, presumably associated with the induction of reactive oxygen species (ROS) production. Only few data are available concerning the effect of miconazole against sessile C. albicans cells. In the present study, the fungicidal activity of miconazole against in vitro-grown mature Candida biofilms, and its relationship with the induction of ROS and ROS-dependent apoptosis were examined.

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