Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniae | Zendy

Hélène Moisan | Zendy; Mireille Pruneau | Zendy; François Malouin | Zendy

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Binding of ceftaroline to penicillin-binding proteins of Staphylococcus aureus and Streptococcus pneumoniae

Author(s) -

Hélène Moisan,

Mireille Pruneau,

François Malouin

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp503

Subject(s) - penicillin binding proteins , microbiology and biotechnology , streptococcus pneumoniae , staphylococcus aureus , penicillin , methicillin resistant staphylococcus aureus , cephalosporin , antibiotics , medicine , bacteria , biology , genetics

This study evaluated the affinity of ceftaroline and comparator beta-lactams for penicillin-binding proteins (PBPs) of methicillin-susceptible Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA) and Streptococcus pneumoniae with varying susceptibility to penicillin. Ceftaroline is currently in Phase 3 development for the treatment of complicated skin and skin structure infections and community-acquired pneumonia, including infections caused by MRSA and multidrug-resistant S. pneumoniae.

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