Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophilia | Zendy

N Claire Gordon | Zendy; David W. Wareham | Zendy

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Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophilia

Author(s) -

N Claire Gordon,

David W. Wareham

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp476

Subject(s) - stenotrophomonas maltophilia , biology , microbiology and biotechnology , escherichia coli , quinolone , enterobacteriaceae , plasmid , amplicon , gene , genetics , polymerase chain reaction , bacteria , antibiotics , pseudomonas aeruginosa

Recent analysis of Stenotrophomonas maltophilia has identified a novel family of resistance genes (Smqnr) encoding pentapeptide repeat proteins, which confer low-level resistance to quinolones. This study describes further novel variants present in clinical isolates of S. maltophilia and investigates their effect on resistance to a number of quinolones in an Escherichia coli host.

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