Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome | Zendy

Michael Hornsey | Zendy; Matthew J. Ellington | Zendy; Michel Doumith | Zendy; S. Hudson | Zendy; David M. Livermore | Zendy; Neil Woodford | Zendy

Open Access

Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome

Author(s) -

Michael Hornsey,

Matthew J. Ellington,

Michel Doumith,

S. Hudson,

David M. Livermore,

Neil Woodford

Publication year - 2010

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp475

Subject(s) - serratia marcescens , tigecycline , efflux , microbiology and biotechnology , ciprofloxacin , enterobacteriaceae , minocycline , cefpirome , serratia , biology , drug resistance , antibiotics , antibiotic resistance , bacteria , escherichia coli , imipenem , biochemistry , genetics , gene , pseudomonas

Efflux by RND-type transporters is known to confer resistance to tigecycline in several Enterobacteriaceae species and we examined the potential of this mechanism in Serratia marcescens using a clinical isolate and laboratory-selected mutants.

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