XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms | Zendy

Nicola Ooi | Zendy; Keith Miller | Zendy; Christopher P. Randall | Zendy; W. RhysWilliams | Zendy; W. Love | Zendy; I. Chopra | Zendy

Open Access

XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms

Author(s) -

Nicola Ooi,

Keith Miller,

Christopher P. Randall,

W. RhysWilliams,

W. Love,

I. Chopra

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp409

Subject(s) - microbiology and biotechnology , staphylococcus aureus , bacteria , biofilm , biology , antibiotics , bacterial growth , genetics

Slow-growing and non-dividing bacteria exhibit tolerance to many antibiotics. However, membrane-active agents may act against bacteria in all growth phases. We sought to examine whether the novel porphyrin antibacterial agents XF-70 and XF-73, which have rapid membrane-perturbing activity against Staphylococcus aureus, retained antistaphylococcal activity against growth-attenuated cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research