Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo | Zendy

Brett L. Mellbye | Zendy; Dwight D. Weller | Zendy; Jed N. Hassinger | Zendy; Matthew D. Reeves | Zendy; Candace Lovejoy | Zendy; Patrick L. Iversen | Zendy; Bruce L. Geller | Zendy

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Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo

Author(s) -

Brett L. Mellbye,

Dwight D. Weller,

Jed N. Hassinger,

Matthew D. Reeves,

Candace Lovejoy,

Patrick L. Iversen,

Bruce L. Geller

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp392

Subject(s) - morpholino , escherichia coli , chemistry , in vivo , peptide , microbiology and biotechnology , biochemistry , stereochemistry , biology , gene knockdown , gene

Phosphorodiamidate morpholino oligomers (PMOs) are uncharged DNA analogues that can inhibit bacterial growth by a gene-specific, antisense mechanism. Attaching cationic peptides to PMOs enables efficient penetration through the Gram-negative outer membrane. We hypothesized that cationic groups attached directly to the PMO would obviate the need to attach peptides.

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