Little evidence for reversibility of trimethoprim resistance after a drastic reduction in trimethoprim use | Zendy

Martin Sundqvist | Zendy; Patricia Geli | Zendy; Dan I. Andersson | Zendy; Maria Sjölund-Karlsson | Zendy; Arne Runehagen | Zendy; Håkan Cars | Zendy; K. Abelson-Storby | Zendy; Otto Cars | Zendy; Gunnar Kahlmeter | Zendy

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Little evidence for reversibility of trimethoprim resistance after a drastic reduction in trimethoprim use

Author(s) -

Martin Sundqvist,

Patricia Geli,

Dan I. Andersson,

Maria Sjölund-Karlsson,

Arne Runehagen,

Håkan Cars,

K. Abelson-Storby,

Otto Cars,

Gunnar Kahlmeter

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp387

Subject(s) - trimethoprim , antibiotics , antibiotic resistance , sulfamethoxazole , escherichia coli , drug resistance , microbiology and biotechnology , biology , antibacterial agent , medicine , biochemistry , gene

The worldwide rapid increase in antibiotic-resistant bacteria has made efforts to prolong the lifespan of existing antibiotics very important. Antibiotic resistance often confers a fitness cost in the bacterium. Resistance may thus be reversible if antibiotic use is discontinued or reduced. To examine this concept, we performed a 24 month voluntary restriction on the use of trimethoprim-containing drugs in Kronoberg County, Sweden.

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