Plasmid-borne blaSHV genes in Klebsiella pneumoniae are associated with strong promoters
Author(s) -
Mark S. Turner,
Per Andersson,
Jan M. Bell,
John Turnidge,
Tegan M. Harris,
Philip M. Giffard
Publication year - 2009
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkp338
Subject(s) - plasmid , klebsiella pneumoniae , biology , gene , promoter , genetics , phenotype , microbiology and biotechnology , gene expression , escherichia coli
Extended-spectrum beta-lactamases (ESBLs) belonging to the SHV family remain a major cause of ESBL-positive phenotypes in Klebsiella pneumoniae. The bla(SHV) gene is a normal constituent of the K. pneumoniae chromosome. However, most ESBL-encoding bla(SHV) genes found in K. pneumoniae are plasmid borne. The objective was to determine the contribution of promoter variants to the expression of plasmid-borne bla(SHV) genes.
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