Open AccessMembrane sterol depletion impairs miltefosine action in wild-type and miltefosine-resistant Leishmania donovani promastigotes
Author(s) -
M. Saint-Pierre-Chazalet,
M. Ben Brahim,
Laurence Le Moyec,
Christian Bories,
Michaëlle Rakotomanga,
Philippe M. Loiseau
Publication year - 2009
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkp321
Subject(s) - miltefosine , leishmania donovani , leishmania , microbiology and biotechnology , biology , sterol , leishmaniasis , visceral leishmaniasis , immunology , biochemistry , parasite hosting , cholesterol , world wide web , computer science
This study focuses on the importance of sterols in the action of miltefosine (hexadecylphosphocholine, HePC) against Leishmania donovani.
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