Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia | Zendy

Kathleen England | Zendy; Christopher am Ende | Zendy; Hao Lu | Zendy; Todd J. Sullivan | Zendy; Nicole L. Marlenee | Zendy; Richard A. Bowen | Zendy; Susan E. Knudson | Zendy; D. L. Knudson | Zendy; Peter J. Tonge | Zendy; Richard A. Slayden | Zendy

Open Access

Substituted diphenyl ethers as a broad-spectrum platform for the development of chemotherapeutics for the treatment of tularaemia

Author(s) -

Kathleen England,

Christopher am Ende,

Hao Lu,

Todd J. Sullivan,

Nicole L. Marlenee,

Richard A. Bowen,

Susan E. Knudson,

D. L. Knudson,

Peter J. Tonge,

Richard A. Slayden

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp307

Subject(s) - francisella tularensis , pharmacokinetics , pharmacology , bioavailability , medicine , broad spectrum , chemistry , biochemistry , combinatorial chemistry , virulence , gene

The National Institute of Allergy and Infectious Disease classifies Francisella tularensis as a Category A priority pathogen. Despite the availability of drugs for treating tularaemia, the mortality in naturally acquired cases can still approach 30%. In addition, the usefulness of existing drugs for treatment in response to exposure or for prophylaxis is limited because of toxicity and delivery concerns. The aim of this study was to assess the efficacy of the lead alkyl-substituted diphenyl ether, SBPT04, in the F. tularensis murine model of infection.

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