In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi | Zendy

Anissa Daliry | Zendy; Patrícia Bento da Silva | Zendy; Cristiane F. da Silva | Zendy; Marcos Meuser Batista | Zendy; Solange L. de Castro | Zendy; Richard R. Tidwell | Zendy; Maria de Nazaré Correia Soeiro | Zendy

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In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi

Author(s) -

Anissa Daliry,

Patrícia Bento da Silva,

Cristiane F. da Silva,

Marcos Meuser Batista,

Solange L. de Castro,

Richard R. Tidwell,

Maria de Nazaré Correia Soeiro

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp290

Subject(s) - amastigote , trypanosoma cruzi , kinetoplast , in vitro , intracellular , biology , cytotoxicity , fluorescence microscope , in vivo , antiparasitic , biochemistry , trypanocidal agent , kinetoplastida , leishmania , subcellular localization , microbiology and biotechnology , dna , fluorescence , trypanosoma brucei , parasite hosting , pathology , physics , quantum mechanics , cytoplasm , world wide web , computer science , gene , medicine

Aromatic diamidines (ADs) have been recognized as promising antiparasitic agents. Therefore, in the present work, the in vitro trypanocidal effect of 11 ADs upon the relevant clinical forms of Trypanosoma cruzi was evaluated, as well as determining their toxicity to mammalian cells and their subcellular localization.

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