Comparative antibacterial effects of daptomycin, vancomycin and teicoplanin studied in an in vitro pharmacokinetic model of infection | Zendy

Karen E. Bowker | Zendy; Alan Noel | Zendy; Alasdair MacGowan | Zendy

Open Access

Comparative antibacterial effects of daptomycin, vancomycin and teicoplanin studied in an in vitro pharmacokinetic model of infection

Author(s) -

Karen E. Bowker,

Alan Noel,

Alasdair MacGowan

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp289

Subject(s) - daptomycin , teicoplanin , vancomycin , staphylococcus aureus , pharmacokinetics , microbiology and biotechnology , medicine , linezolid , methicillin resistant staphylococcus aureus , antibacterial agent , antibiotics , in vitro , pharmacology , chemistry , biology , bacteria , genetics , biochemistry

To compare the antibacterial effects (ABEs) of the free (f) drugs daptomycin, vancomycin and teicoplanin against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), using high and low inocula in a pharmacokinetic in vitro model. To determine the daptomycin fAUC/MIC ratio for a static effect and 3 log reduction in viable count and relate this target to the clinical breakpoint.

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