The impact of duration of antibiotic exposure on bacterial resistance predictions using in vitro dynamic models | Zendy

Maria V. Smirnova | Zendy; Sergey N. Vostrov | Zendy; Ele. Strukova | Zendy; Svetlana A. Dovzhenko | Zendy; Mikhail B. Kobrin | Zendy; Yury A. Portnoy | Zendy; Stephen H. Zinner | Zendy; Alexander A. Firsov | Zendy

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The impact of duration of antibiotic exposure on bacterial resistance predictions using in vitro dynamic models

Author(s) -

Maria V. Smirnova,

Sergey N. Vostrov,

Ele. Strukova,

Svetlana A. Dovzhenko,

Mikhail B. Kobrin,

Yury A. Portnoy,

Stephen H. Zinner,

Alexander A. Firsov

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp287

Subject(s) - antibiotic resistance , microbiology and biotechnology , antibiotics , in vitro , duration (music) , biology , medicine , physics , genetics , acoustics

To explore whether the duration of in vitro simulated antibiotic exposure influences bacterial resistance, time-dependent amplification of resistant subpopulations of Staphylococcus aureus was studied in 10 day simulations in a dynamic model with daptomycin as a prototypic agent.

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