Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells | Zendy

D. F. SMEE | Zendy; Brett L. Hurst | Zendy; Hiroyuki Egawa | Zendy; Kohei Takahashi | Zendy; Takumi Kadota | Zendy; Yoshihiko Furuta | Zendy

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Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells

Author(s) -

D. F. SMEE,

Brett L. Hurst,

Hiroyuki Egawa,

Kohei Takahashi,

Takumi Kadota,

Yoshihiko Furuta

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp274

Subject(s) - intracellular , extracellular , favipiravir , virus , biology , marburg virus , influenza a virus , microbiology and biotechnology , virology , biochemistry , medicine , disease , covid-19 , ebola virus , infectious disease (medical specialty)

To determine the metabolism of favipiravir (T-705, 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) to its ribosylated, triphosphorylated form (T-705 RTP) in uninfected and influenza A/Duck/MN/1525/81 (H5N1) virus-infected cells. Effects of treatment on intracellular guanosine triphosphate (GTP) pools and influenza virus-inhibitory activity were also assessed.

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