Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant | Zendy

Gabriel Mircus | Zendy; Shelly Hagag | Zendy; Emma Levdansky | Zendy; Haggai Sharon | Zendy; Yona Shadkchan | Zendy; Itamar Shalit | Zendy; Nir Osherov | Zendy

Open Access

Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant

Author(s) -

Gabriel Mircus,

Shelly Hagag,

Emma Levdansky,

Haggai Sharon,

Yona Shadkchan,

Itamar Shalit,

Nir Osherov

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp270

Subject(s) - aspergillus nidulans , aspergillus fumigatus , cell wall , caspofungin , antifungal drug , mutant , biology , microbiology and biotechnology , candida albicans , biochemistry , voriconazole , antifungal , gene

Despite the need for novel drugs to combat fungal infections, antifungal drug discovery is currently limited by both the availability of suitable drug targets and assays to screen corresponding targets. The aim of this study was to screen a library of small chemical compounds to identify cell wall inhibitors using a conditional protein kinase C (PKC)-expressing strain of Aspergillus nidulans. This mutant is specifically susceptible to cell wall damaging compounds under PKC-repressive growth conditions.

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