Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines | Zendy

Sandrine Lemaire | Zendy; Françoise Van Bambeke | Zendy; Peter C. Appelbaum | Zendy; Paul M. Tulkens | Zendy

Open Access

Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines

Author(s) -

Sandrine Lemaire,

Françoise Van Bambeke,

Peter C. Appelbaum,

Paul M. Tulkens

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp267

Subject(s) - listeria monocytogenes , intracellular , staphylococcus aureus , linezolid , thp1 cell line , microbiology and biotechnology , legionella pneumophila , macrophage , context (archaeology) , pharmacokinetics , antibiotics , intracellular parasite , cell culture , antibacterial agent , biology , chemistry , pharmacology , bacteria , in vitro , biochemistry , vancomycin , genetics , paleontology

Optimal treatment of infections caused by Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila requires antibiotics with intracellular activity. Linezolid accumulates poorly within cells. Torezolid (TR-700) is a novel methyltetrazolyl oxazolidinone with potentially different cellular pharmacokinetic properties. Our aim was to examine the accumulation and intracellular activities of torezolid in this context.

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