High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection | Zendy

Michael Schintler | Zendy; Friederike Traunmüller | Zendy; Julia Metzler | Zendy; G. Kreuzwirt | Zendy; Stephan Spendel | Zendy; O. Mauric | Zendy; Martin Popovic | Zendy; E. Scharnagl | Zendy; Christian Joukhadar | Zendy

Open Access

High fosfomycin concentrations in bone and peripheral soft tissue in diabetic patients presenting with bacterial foot infection

Author(s) -

Michael Schintler,

Friederike Traunmüller,

Julia Metzler,

G. Kreuzwirt,

Stephan Spendel,

O. Mauric,

Martin Popovic,

E. Scharnagl,

Christian Joukhadar

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp230

Subject(s) - fosfomycin , daptomycin , medicine , staphylococcus aureus , diabetic foot , soft tissue , methicillin resistant staphylococcus aureus , bone infection , osteomyelitis , antimicrobial , vancomycin , surgery , microbiology and biotechnology , diabetes mellitus , bacteria , biology , endocrinology , genetics

Appropriate antimicrobial therapy and surgical intervention may be required in diabetic patients presenting with severe bacterial foot infection. Methicillin-resistant Staphylococcus aureus (MRSA) agents such as fosfomycin are increasingly in demand because of recent concern regarding vancomycin and daptomycin efficacy and constant use. Intravenous fosfomycin is approved for the therapy of severe soft tissue infections and is highly active against methicillin-susceptible S. aureus and MRSA. in the present study we investigated fosfomycin's ability to penetrate bone tissue in diabetic patients suffering from severe bacterial foot infection.

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