Anti-Acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent | Zendy

Julia Walochnik | Zendy; Andreas Obwaller | Zendy; Флориан Грубер | Zendy; Michael Mildner | Zendy; Erwin Tschachler | Zendy; Miranda Suchomel | Zendy; Michael Duchêne | Zendy; Herbert Auer | Zendy

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Anti-Acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent

Author(s) -

Julia Walochnik,

Andreas Obwaller,

Флориан Грубер,

Michael Mildner,

Erwin Tschachler,

Miranda Suchomel,

Michael Duchêne,

Herbert Auer

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp215

Subject(s) - miltefosine , acanthamoeba , acanthamoeba keratitis , keratitis , medicine , microbiology and biotechnology , biocide , toxicity , dermatology , biology , immunology , pharmacology , pathology , leishmaniasis , visceral leishmaniasis

Acanthamoebae can cause infections of several organs, including eye, skin, lung and brain. Except for Acanthamoeba keratitis, these infections are linked to immunodeficiency. Treatment is generally problematic, due to the lack of sufficiently effective and also easily manageable drugs. In a previous study we discovered that miltefosine (hexadecylphosphocholine) is highly active against Acanthamoeba spp. in vitro. The aim of the current study was to evaluate the suitability of miltefosine for the topical treatment of Acanthamoeba infections.

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