HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations | Zendy

César Garriga | Zendy; María Jesús PérezElías | Zendy; Rafaël Delgado | Zendy; Lı́dia Ruiz | Zendy; Lucía Pérez-Álvarez | Zendy; Tomàs Pumarola | Zendy; A. López-Lirola | Zendy; Juan GonzálezGarcía | Zendy; Luis MenéndezArias | Zendy

Open Access

HIV-1 reverse transcriptase thumb subdomain polymorphisms associated with virological failure to nucleoside drug combinations

Author(s) -

César Garriga,

María Jesús PérezElías,

Rafaël Delgado,

Lı́dia Ruiz,

Lucía Pérez-Álvarez,

Tomàs Pumarola,

A. López-Lirola,

Juan GonzálezGarcía,

Luis MenéndezArias

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp200

Subject(s) - nucleoside reverse transcriptase inhibitor , reverse transcriptase , didanosine , human immunodeficiency virus (hiv) , reverse transcriptase inhibitor , virology , medicine , drug , biology , sida , viral disease , antiretroviral therapy , pharmacology , genetics , polymerase chain reaction , viral load , gene

The aim of this study was to identify mutations within the fingers, palm and thumb subdomains of the HIV-1 reverse transcriptase (RT) associated with therapy failure to various combinations of two nucleoside analogues.

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