Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada | Zendy

Shelly Bolotin | Zendy; David C. Alexander | Zendy; Pamela Chedore | Zendy; Steven J. Drews | Zendy; F. Jamieson | Zendy

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Molecular characterization of drug-resistant Mycobacterium tuberculosis isolates from Ontario, Canada

Author(s) -

Shelly Bolotin,

David C. Alexander,

Pamela Chedore,

Steven J. Drews,

F. Jamieson

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp183

Subject(s) - rpob , inha , isoniazid , rifampicin , mycobacterium tuberculosis , biology , tuberculosis , drug resistance , microbiology and biotechnology , multiple drug resistance , virology , antibiotics , medicine , pathology

Ontario bears the greatest burden of tuberculosis in Canada, with 40% of all cases and 60% of multidrug-resistant cases. The purpose of this study was to genotypically characterize isoniazid- and rifampicin-resistant isolates and compare these results with phenotypic drug susceptibility testing data. This is the first Canadian study to examine gene mutations that contribute to multidrug-resistant tuberculosis.

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