Combination therapy with micafungin and amphotericin B for invasive pulmonary aspergillosis in an immunocompromised mouse model | Zendy

Yoji Nagasaki | Zendy; Yoshihiro Eriguchi | Zendy; Yukiko Uchida | Zendy; Noriko Miyake | Zendy; Yoshihiko Maehara | Zendy; Masako Kadowaki | Zendy; M Harada | Zendy; Koichi Akashi | Zendy; Nobuyuki Shimono | Zendy

Open Access

Combination therapy with micafungin and amphotericin B for invasive pulmonary aspergillosis in an immunocompromised mouse model

Author(s) -

Yoji Nagasaki,

Yoshihiro Eriguchi,

Yukiko Uchida,

Noriko Miyake,

Yoshihiko Maehara,

Masako Kadowaki,

M Harada,

Koichi Akashi,

Nobuyuki Shimono

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp175

Subject(s) - micafungin , echinocandins , amphotericin b , aspergillosis , combination therapy , pulmonary aspergillosis , medicine , echinocandin , mycosis , pharmacology , microbiology and biotechnology , antifungal , immunology , caspofungin , biology , dermatology , fluconazole

Antifungal monotherapy with polyenes, azoles or echinocandins is not always effective for invasive pulmonary aspergillosis (IPA). The main purpose of this study was to evaluate the efficacy of a combination of micafungin and amphotericin B for the primary treatment of IPA in an immunocompromised mouse model.

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