Antimicrobial and antibiofilm efficacy of triclosan and DispersinB(R) combination | Zendy

Rabih O. Darouiche | Zendy; Mohammad D. Mansouri | Zendy; Purushottam V. Gawande | Zendy; Srinivasa Madhyastha | Zendy

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Antimicrobial and antibiofilm efficacy of triclosan and DispersinB(R) combination

Author(s) -

Rabih O. Darouiche,

Mohammad D. Mansouri,

Purushottam V. Gawande,

Srinivasa Madhyastha

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp158

Subject(s) - triclosan , antimicrobial , microbiology and biotechnology , staphylococcus aureus , staphylococcus epidermidis , in vivo , biofilm , chemistry , medicine , biology , bacteria , genetics , pathology

The objectives of this study were to examine: (i) synergy of the combination of triclosan and DispersinB (DspB); (ii) in vitro efficacy and durability of triclosan + DspB-coated vascular catheters; and (iii) in vivo efficacy of triclosan + DspB-coated catheters compared with chlorhexidine-silver sulfadiazine (CH-SS)-coated and uncoated (control) vascular catheters in preventing colonization by Staphylococcus aureus.

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