Lysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice | Zendy

John F. Kokai–Kun | Zendy; Tanya Chanturiya | Zendy; James J. Mond | Zendy

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Lysostaphin eradicates established Staphylococcus aureus biofilms in jugular vein catheterized mice

Author(s) -

John F. Kokai–Kun,

Tanya Chanturiya,

James J. Mond

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp145

Subject(s) - lysostaphin , staphylococcus aureus , microbiology and biotechnology , antibiotics , medicine , biofilm , biology , bacteria , genetics

Staphylococcus aureus infections associated with indwelling devices can be very difficult to treat due to the recalcitrant nature of bacterial biofilms to conventional antibiotics. Lysostaphin has been shown to clear S. aureus biofilms in vitro, and in this study we determined whether lysostaphin could also eradicate established S. aureus biofilms on implanted jugular vein catheters in mice.

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