Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium | Zendy

Geoffrey A. McKay | Zendy; Sylvain Beaulieu | Zendy; Francis F. Arhin | Zendy; Adam Belley | Zendy; Ingrid Sarmiento | Zendy; Thomas Parr | Zendy; Greg Moeck | Zendy

Open Access

Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium

Author(s) -

Geoffrey A. McKay,

Sylvain Beaulieu,

Francis F. Arhin,

Adam Belley,

Ingrid Sarmiento,

Thomas Parr,

Greg Moeck

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp126

Subject(s) - linezolid , teicoplanin , enterococcus faecium , microbiology and biotechnology , enterococcus faecalis , staphylococcus aureus , daptomycin , vancomycin , enterococcus , methicillin resistant staphylococcus aureus , chemistry , antibiotics , biology , bacteria , genetics

Oritavancin, a lipoglycopeptide, possesses bactericidal activity against Gram-positive bacteria including vancomycin-resistant Staphylococcus aureus and enterococci. To understand the time dependence of oritavancin activity, we have undertaken time-kill experiments against isolates of S. aureus, Enterococcus faecalis and Enterococcus faecium, including recent antibiotic-resistant strains.

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