Population analysis of the pregnancy-related modifications in lopinavir pharmacokinetics and their possible consequences for dose adjustment | Zendy

Marion BouillonPichault | Zendy; Vincent Jullien | Zendy; Élie Azria | Zendy; E. Pannier | Zendy; Ghislaine Firtion | Zendy; Anne Krivine | Zendy; Alexandra Compagnucci | Zendy; Olivier Tauléra | Zendy; Laurent Finkielsztejn | Zendy; Stéphanie Chhun | Zendy; Guillem Pons | Zendy; Odile Launay | Zendy; JeanMarc Tréluyer | Zendy

Open Access

Population analysis of the pregnancy-related modifications in lopinavir pharmacokinetics and their possible consequences for dose adjustment

Author(s) -

Marion BouillonPichault,

Vincent Jullien,

Élie Azria,

E. Pannier,

Ghislaine Firtion,

Anne Krivine,

Alexandra Compagnucci,

Olivier Tauléra,

Laurent Finkielsztejn,

Stéphanie Chhun,

Guillem Pons,

Odile Launay,

JeanMarc Tréluyer

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp123

Subject(s) - lopinavir , medicine , pregnancy , pharmacokinetics , population , regimen , lopinavir/ritonavir , gestation , gestational age , obstetrics , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , immunology , biology , environmental health , genetics

To investigate the possible necessity of an increase in lopinavir dose during pregnancy in order to achieve the concentrations previously defined as predictive of virological efficacy.

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