Open AccessMLST typing of Escherichia coli isolates overproducing AmpC -lactamase
Author(s) -
A. Guillouzouic,
Nathalie Caroff,
Sandie Dauvergne,
Didier Lepelletier,
Agnès PerrinGuyomard,
Isabelle Kempf,
Alain Reynaud,
Stéphane Corvec
Publication year - 2009
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkp099
Subject(s) - escherichia coli , overproduction , microbiology and biotechnology , biology , bacteria , pathogen , rna polymerase , homology (biology) , cephalosporin , multilocus sequence typing , gene , genetics , antibiotics , genotype
Escherichia coli is the major commensal aerobic bacterium of the digestive tract of humans and animals, but is also the most frequent human bacterial pathogen. As a consequence, resistance mechanisms carried by this species are of particular concern. One of these mechanisms is the overproduction of the chromosomal AmpC β-lactamase, leading to increased MICs of most β-lactams including third-generation cephalosporins. AmpC overproduction is caused by various mutations in the ampC promoter (–42, –32 and –11) increasing homology with the consensus promoter for RNA polymerase
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