Open AccessAnalysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques
Author(s) -
Anna Vickers,
Nicola J. Potter,
Colin W. G. Fishwick,
I. Chopra,
Alex J. O’Neill
Publication year - 2009
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkp090
Subject(s) - dihydrofolate reductase , trimethoprim , biology , mutant , staphylococcus aureus , genetics , genotype , microbiology and biotechnology , mutation , gene , antibiotics , bacteria
This study sought to expand knowledge on the molecular mechanisms of mutational resistance to trimethoprim in Staphylococcus aureus, and the fitness costs associated with resistance.
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