Development and evaluation of vancomycin dosage guidelines designed to achieve new target concentrations
Author(s) -
Alison H. Thomson,
Christine E. Staatz,
C. M. Tobin,
M.A. Gall,
Andrew Lovering
Publication year - 2009
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkp085
Subject(s) - vancomycin , nonmem , trough concentration , pharmacokinetics , therapeutic drug monitoring , medicine , population , antibacterial agent , pharmacology , antibiotics , microbiology and biotechnology , biology , staphylococcus aureus , environmental health , bacteria , genetics
The aims of this study were to develop a population pharmacokinetic model of vancomycin in adult patients, to use this model to develop dosage guidelines targeting vancomycin trough concentrations of 10-15 mg/L and to evaluate the performance of these new guidelines.
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