Evidence that impurities contribute to the fluorescence of the polyene antibiotic amphotericin B | Zendy

Jacques Bolard | Zendy; John D. Cleary | Zendy; Robert Krämer | Zendy

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Evidence that impurities contribute to the fluorescence of the polyene antibiotic amphotericin B

Author(s) -

Jacques Bolard,

John D. Cleary,

Robert Krämer

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp059

Subject(s) - polyene , amphotericin b , antibiotics , fluorescence , chemistry , fluorescence spectroscopy , microbiology and biotechnology , biochemistry , antifungal , biology , physics , quantum mechanics

Based on the assertion that fluorescence spectroscopy detects dimers of the polyene antibiotic amphotericin B (AmB), this technique was recently proposed to analyse the interaction of the drug with cell membranes. However, contradictory results indicate that this 'dimeric' fluorescence might actually originate from polyene impurities. We used a highly purified AmB to challenge this last proposal.

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