Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages | Zendy

Nicola J. Beresford | Zendy; Debbie C. Mulhearn | Zendy; Bruce G. Szczepankiewicz | Zendy; Gang Liu | Zendy; Michael E. Johnson | Zendy; Anthony P. FordhamSkelton | Zendy; Cele AbadZapatero | Zendy; Jim Cavet | Zendy; Lydia Tabernero | Zendy

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Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages

Author(s) -

Nicola J. Beresford,

Debbie C. Mulhearn,

Bruce G. Szczepankiewicz,

Gang Liu,

Michael E. Johnson,

Anthony P. FordhamSkelton,

Cele AbadZapatero,

Jim Cavet,

Lydia Tabernero

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp031

Subject(s) - mycobacterium tuberculosis , microbiology and biotechnology , tuberculosis , biology , mycobacterium , virulence , virulence factor , in vitro , protein tyrosine phosphatase , enzyme , bacteria , biochemistry , medicine , genetics , pathology , gene

The secreted Mycobacterium tuberculosis protein tyrosine phosphatase (MptpB) is a virulence factor for M. tuberculosis and contributes to its survival within host macrophages. The aim of this study was to identify potent selective inhibitors of MptpB and to determine the efficacy of these compounds in mycobacterium-infected macrophages.

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