Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation | Zendy

Isabel Spriet | Zendy; Pieter Annaert | Zendy; Philippe Meersseman | Zendy; Greet Hermans | Zendy; Wouter Meersseman | Zendy; R. Verbesselt | Zendy; Ludo Willems | Zendy

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Pharmacokinetics of caspofungin and voriconazole in critically ill patients during extracorporeal membrane oxygenation

Author(s) -

Isabel Spriet,

Pieter Annaert,

Philippe Meersseman,

Greet Hermans,

Wouter Meersseman,

R. Verbesselt,

Ludo Willems

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp026

Subject(s) - voriconazole , pharmacokinetics , extracorporeal membrane oxygenation , caspofungin , medicine , volume of distribution , extracorporeal , pharmacology , anesthesia , therapeutic drug monitoring , antifungal , dermatology

During extracorporeal membrane oxygenation (ECMO), drug disposition changes significantly. Plasma concentrations are altered due to an expanded circulating volume leading to a decreased elimination. In addition, adsorption and sequestration of drugs by the ECMO circuit components may further alter pharmacokinetics. Treating patients during the ECMO period with antifungals is difficult. Loss in the ECMO circuit can potentially result in sub-therapeutic levels.

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