TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens | Zendy

R. N. Jones | Zendy; Gj Moet | Zendy; Hélio S. Sader | Zendy; Rodrigo E. Mendes | Zendy; Mariana Castanheira | Zendy

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TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogens

Author(s) -

R. N. Jones,

Gj Moet,

Hélio S. Sader,

Rodrigo E. Mendes,

Mariana Castanheira

Publication year - 2009

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkp021

Subject(s) - linezolid , 23s ribosomal rna , microbiology and biotechnology , broth microdilution , biology , enterococcus faecalis , enterococcus faecium , staphylococcus aureus , enterococcus , staphylococcus , clindamycin , antibiotics , minimum inhibitory concentration , bacteria , vancomycin , genetics , gene , ribosome , rna

TR-700, the active component of the oxazolidinone prodrug TR-701, has demonstrated potent activity against numerous Gram-positive species. In this study, single-step mutation frequencies, passaging and the activity of TR-700 were tested against a worldwide collection of linezolid-non-susceptible organisms and matched controls.

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