Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis | Zendy

Richard A. Slayden | Zendy; John T. Belisle | Zendy

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Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis

Author(s) -

Richard A. Slayden,

John T. Belisle

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn507

Subject(s) - mycobacterium tuberculosis , microbiology and biotechnology , biology , signature (topology) , tuberculosis , gene , virology , gene signature , bacterial protein , genetics , medicine , pathology , gene expression , geometry , mathematics

Universally conserved events in cell division provide the opportunity for the development of novel chemotherapeutics against Mycobacterium tuberculosis. The aim of this study was to use the beta-lactam antimicrobials cefalexin and piperacillin to inhibit FtsI and characterize the morphological changes and global transcriptional activities of genes to identify a signature response to FtsI inactivation.

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