Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model | Zendy

Simon D. Baines | Zendy; Rory O’Connor | Zendy; Katherine Saxton | Zendy; Jane Freeman | Zendy; M. H. Wilcox | Zendy

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Activity of vancomycin against epidemic Clostridium difficile strains in a human gut model

Author(s) -

Simon D. Baines,

Rory O’Connor,

Katherine Saxton,

Jane Freeman,

M. H. Wilcox

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn502

Subject(s) - vancomycin , clostridium difficile , metronidazole , clindamycin , microbiology and biotechnology , biology , antibiotics , clostridium difficile toxin a , clostridium , ribotyping , bacteria , polymerase chain reaction , staphylococcus aureus , gene , biochemistry , genetics

Vancomycin and metronidazole remain the only primary options for the treatment of Clostridium difficile infection (CDI). Recent reports have suggested a superior clinical response to vancomycin therapy compared with metronidazole, but this has been difficult to prove or explain. There are few robust in vitro data of the effects of antibiotic treatment of CDI in a gut reflective setting.

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