Paradoxical effect of 1-(1-naphthylmethyl)-piperazine on resistance to tetracyclines in multidrug-resistant Acinetobacter baumannii | Zendy

David C. Bean | Zendy; David W. Wareham | Zendy

Open Access

Paradoxical effect of 1-(1-naphthylmethyl)-piperazine on resistance to tetracyclines in multidrug-resistant Acinetobacter baumannii

Author(s) -

David C. Bean,

David W. Wareham

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn493

Subject(s) - tigecycline , acinetobacter baumannii , minocycline , microbiology and biotechnology , tetracycline , etest , multiple drug resistance , efflux , biology , doxycycline , colistin , antibiotics , bacteria , biochemistry , genetics , pseudomonas aeruginosa

The efflux inhibitor 1-(1-naphthylmethyl)-piperazine (NMP) has been demonstrated to reverse multidrug resistance in Acinetobacter baumannii. We investigated the interaction of NMP with tigecycline and three other tetracyclines on clinical isolates of A. baumannii.

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