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The aim of the study was to test the hypothesis that the efflux pump inhibitors (EPIs) 1-(1-naphthylmethyl)-piperazine (NMP) and phenyl-arginine-beta-naphthylamide (PAbetaN) can inhibit the Vibrio cholerae resistance-nodulation-division (RND) family efflux systems, and thereby render V. cholerae susceptible to antimicrobial agents and inhibit the production of the virulence factors cholera toxin (CT) and the toxin coregulated pilus (TCP).

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Effect of the efflux inhibitors 1-(1-naphthylmethyl)-piperazine and phenyl-arginine- -naphthylamide on antimicrobial susceptibility and virulence factor production in Vibrio cholerae