Effect of the efflux inhibitors 1-(1-naphthylmethyl)-piperazine and phenyl-arginine- -naphthylamide on antimicrobial susceptibility and virulence factor production in Vibrio cholerae | Zendy

X. Renee Bina | Zendy; J. A. Philippart | Zendy; James E. Bina | Zendy

Open Access

Effect of the efflux inhibitors 1-(1-naphthylmethyl)-piperazine and phenyl-arginine- -naphthylamide on antimicrobial susceptibility and virulence factor production in Vibrio cholerae

Author(s) -

X. Renee Bina,

J. A. Philippart,

James E. Bina

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn466

Subject(s) - efflux , vibrio cholerae , microbiology and biotechnology , biology , cholera toxin , virulence factor , antimicrobial , virulence , biochemistry , bacteria , gene , genetics

The aim of the study was to test the hypothesis that the efflux pump inhibitors (EPIs) 1-(1-naphthylmethyl)-piperazine (NMP) and phenyl-arginine-beta-naphthylamide (PAbetaN) can inhibit the Vibrio cholerae resistance-nodulation-division (RND) family efflux systems, and thereby render V. cholerae susceptible to antimicrobial agents and inhibit the production of the virulence factors cholera toxin (CT) and the toxin coregulated pilus (TCP).

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