Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle | Zendy

John G. D’Angelo | Zendy; Claudia Bordón | Zendy; Gary H. Posner | Zendy; Robert H. Yolken | Zendy; Lorraine JonesBrando | Zendy

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Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle

Author(s) -

John G. D’Angelo,

Claudia Bordón,

Gary H. Posner,

Robert H. Yolken,

Lorraine JonesBrando

Publication year - 2008

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkn451

Subject(s) - toxoplasma gondii , lytic cycle , antiparasitic , in vitro , cytotoxicity , biology , artemisinin , toxoplasmosis , cytotoxic t cell , antiparasitic agent , growth inhibition , chemistry , virology , microbiology and biotechnology , biochemistry , plasmodium falciparum , pharmacology , immunology , malaria , virus , antibody , medicine , pathology

We sought to improve upon the usefulness of artemisinins as anti-Toxoplasma agents by synthesizing new unsaturated, carba derivatives and then testing them for in vitro efficacy against three steps of the lytic cycle of Toxoplasma gondii tachyzoites.

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